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Basenji PRA type 1             Bas_PRA1 Test         Code 301

 

Test Pricing

For breeds: Basenji

 

Basenji PRA Mutation Identified:

Canine genetic researchers, Goldstein et al. at Cornell University Veterinary Medicine's James Baker Institute for Animal Health, have identified a mutation that is responsible for PRA in the Basenji. OptiGen is pleased to now provide the Basenji community with a DNA test, Bas_PRA1, for this important disease.

 

Brief Description of Basenji PRA:

The form of PRA that is caused by the Bas_PRA1 mutation is typically first diagnosed when dogs are, on average, five years of age.  The initial symptoms consist of retinal thinning marked by vascular attenuation. Similar to most other forms of PRA, retinal degeneration progresses gradually and ultimately results in complete blindness. There is currently no cure for PRA.

 

Similar to almost every identified cause of PRA in the dog, Bas_PRA1 is inherited in an autosomal recessive manner. This means that Bas_PRA1 disease will occur only if two copies of the mutation are present; carriers of one copy of the mutation do not show disease. By ensuring that at least one parent is Normal/Clear of Bas_PRA1 then no offspring affected with this disease will be produced in a mating. See chart below for expected breeding outcomes when the Bas_PRA1 status (Genotype) has been determined by DNA testing.

 

Other Forms of PRA:

Although the Bas_PRA1 mutation explained the majority of clinical cases of PRA examined in the study, unfortunately there are still a few cases of PRA in the Basenji that are known to not be caused by this mutation. These cases will continue to be a subject of ongoing PRA research. If you know of any PRA-affected Basenji, please encourage the owners to contact OptiGen to learn about our Free PRA testing/research program: http://www.optigen.com/opt9_research.html

 

 

Expected results for breeding strategies using the
Bas_PRA1 test
Parent 1
Genotype
Parent 2 Genotype
Normal/ClearCarrierAffected
Normal/ClearAll = Normal/Clear1/2 = Normal/Clear
1/2 = Carrier
All = Carrier
Carrier1/2 = Normal
1/2 = Carrier
1/4 = Normal/Clear
1/2 = Carrier
1/4 = Affected
1/2 = Carrier
1/2 = Affected
Affected All = Carrier
1/2 = Carrier
1/2 = Affected
All = Affected

Samples included in the Cornell University Basenji PRA research:
If you submitted samples to the Acland/Aguirre laboratory at James Baker Institute for Animal Health as part of the Basenji PRA research project and would like to inquire as to whether Bas_PRA1 research results are available on the sample, please contact OptiGen at genetest@optigen.com for further details.


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