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Retinal Disease Studies: Publications from the Inherited Eye Disease Studies Unit, Baker Institute, Cornell University

NOVEMBER 2002

For abstracts of many of the following articles, go to
the National Library of Science publications search service and search for Aguirre GD" or "Acland GM".

  1. Zhu L, Jang GF, Jastrzebska B, Filipek S, Pearce-Kelling SE, Aguirre GD, Stenkamp RE, Acland GM, Palczewski K. A Naturally Occurring Mutation of the Opsin Gene (T4R) in Dogs Affects Glycosylation an Stability of the G Protein-coupled Receptor. J Biol Chem. 2004 Dec 17;279(51)53828-39. Epub 2004 Sep 30.

  2. Casse C, Acland GM, Aguirre GD. Cloning and mapping of canine KIAA1753. Anim Genet. 2004 Aug;35(4):358-9. No abstract available.

  3. Kukekova AV, Trut LN, Oskina IN, Kharlamova AV, Shikhevich SG, Kirkness EF, Aguirre GD, Acland GM. A marker set for construction of a genetic map of the silver fox (Vulpes vulpes). J Hered. 2004 May-Jun;95(3):185-94.

  4. Kijas JW, Zangerl B, Miller B, Nelson J, Kirkness EF, Aguirre GD, Acland GM. Cloning of the canine ABCA4 gene and evaluation in canine cone-rod dystrophies and progressive retinal atrophies. Mol Vis 2004 Mar 29; 10:223-32.

  5. Zhang Q, Beltran WA, Mao Z, Li K, Johnson JL, Acland GM, Aguirre GD. Comparative analysis and expression of CLUL1, a cone photoreceptor-specific gene. Invest Ophthalmol Vis Sci 2003 Oct;44(10):4542-9.

  6. Kukekova AV, Aguirre GD, Acland GM. Cloning and characterization of canine SHARP1 and its evaluation as a positional candidate for canine early retinal degeneration (erd). Gene.2003 Jul 17;312:335-43.

  7. Beltran WA, Zhang Q, Kijas JW, Gu D, Rohrer H, Jordan JA, Aguirre GD. Cloning, mapping, and retinal expression of the canine ciliary neurotrophic factor receptor alpha (CNTFRalpha). Invest Ophthalmol Vis Sci.2003 Aug;44(8)3642-9

  8. Lowe JK, Kukekova AV, Kirkness EF, Langlois MC, Aguirre GD, Acland GM, Ostrander EA. Linkage mapping of the primary disease locus for collie eye anomaly. Genomics. 2003 Jul;82(1)86-95.

  9. Kijas JW, Miller BJ, Pearce-Kelling SE, Aguirre GD, Acland GM. Canine models of ocular disease: outcross breedings define a dominant disorder present in the English mastiff and bull mastiff dog breeds. J Hered.2003 Jan-Feb;94(1):27-30.

  10. Li K, Zhang Q, Johnson JL, Aguirre GD. Comparative analysis, gene organization and expression of canine TCTE1L. Gene.2003 Jan 16;303:207-12.

  11. Sidjanin DJ, Zangerl B, Johnson JL, Xue F, Mellersh C, Ostrander EA, Acland GM, Aguirre GD. Cloning of the canine delta tubulin cDNA (TUBD)and mapping to CFA9. Anim Genet. 2002 Apr;33(2):161-2. No abstract available.

  12. Aquirre GD, Yashar BM, John SK, Smith JE, Breuer DK, Hiriyanna S, Swaroop A, Milam AH. Retinal Histopathology of an XLRP Carrier with a Mutation in the RPGR Exon ORF15. Exp Eye Res. 2002 Oct; 75(4):431.

  13. Tao W, Wen R, Goddard MB, Sherman SD, O'Rourke PJ, Stabila PF, Bell WJ, Dean BJ, Kauper KA, Budz VA, Tsiaras WG, Acland GM, Pearce-Kelling S, Laties AM, Aguirre GD. Encapsulated cell-based delivery of CNTF reduces photoreceptor degeneration in animal models of retinitis pigmentosa. Invest Ophthalmol Vis Sci. 2002 Oct; 43(10):3292-8.

  14. Zangerl B, Zhang Q, Pearce-Kelling S, Aguirre GD. Molecular cloning, characterization and mapping fo the canine glucocorticoid receptor DNA binding factor 1 (GRLF1). Gene. 2002 Jul 10; 294(1-2):167.

  15. Sidjanin DJ, Lowe JK, McElwee JL, Milne BS, Phippen TM, Sargan DR, Aguirre GD, Acland GM, Ostrander EA. Canine CNGB3 mutations establish cone degeneration as orthologous to the human achromatopsia locus ACHM3. Hum Mol Genet. 2002 Aug 1;11(16):1823-33.

  16. Zangerl B, Zhang Q, Acland GM, Aguirre GD. Characterization of Three Microsatellite Loci Linked to the Canine RP3 Interval. J Hered. 2002 Jan-Feb;93(1):70-3.

  17. Meyers VN, Jezyk PF, Aguirre GD, Patterson DF. Short-limbed dwarfism and ocular defects in the Samoyed dog. J AM Vet Med Assoc. 1983 Nov 1;183(9);975-9.

  18. Zhang Q, Acland GM, Wu WX, Johnson JL, Pearce-Kelling S, Tulloch B, Vervoort R, Wright AF, Aguirre GD. Different RPGR exon ORF15 mutations in Canids provide insights into photoreceptor cell degeneration. Hum Mol Genet. 2002 May 1, 11(9):993-1003.

  19. Kijas JW, Cideiyan AV, Aleman T, Pianta MJ, Pearce-Kelling SE, Miller BJ, Jacobson SG, Aguirre GD, Acland GM. Naturally occurring rhodopsin mutation in the dog causes retinal dysfunction and degeneration mimicking human dominant retinitis pigmentosa. PNAS 2002 Apr 30, 99(9):6328-6333.

  20. Akhmedov NB, Baldwin VJ, Zangerl B, Kijas JW, Hunter L, Minoofar KD, Mellersh C, Ostrander EA, Acland GM, Farber DB, Aguirre GD. Cloning and characterization of the canine photoreceptor specific cone-rod homeobox (CRX) gene and evaluation as a candidate for early onset photoreceptor diseases in the dog. Mol Vis. 2002 Mar 22, 8:79-84.

  21. Verdugo ME, Scarpino V, Moullier P, Haskins ME, Aguirre GD, Ray J. Adenoviral vector-mediated beta-glucuronidase cDNA transfer to treat MPS VII RPE in vitro. Curr Eye Res. 2001 Nov; 23(5):357-67.

  22. Milam AH, DeCastro EB, Smith JE, Tang WX, John SK, Gorin MB, Stone EM, Aguirre GD, Jacobson SG. Concentric retinitis pigmentosa: clinicopathologic correlations. Exp Eye Res. 2001 Oct; 73(4):493-508.

  23. Sidjanin DJ, Xue F, McElwee J, Johnson JL, Holmgren C, Mellersh C, Ostrander E, Acland GM, Aguirre GD. Cloning of canine gamma-tubulin (TUBG1)cDNA and mapping to CFA9. Anim Genet. 2001 Oct;32(5):328-9.

  24. Zhang Q, Acland GM, Zangerl B, Johnson JL, Mao Z, Zeiss CJ, Ostrander EA, Aguirre GD. Fine mapping of canine XLPRA establishes homology of the human and canine RP3 intervals. Invest Ophthalmol Vis Sci. 2001 Oct;42(11):2466-71.

  25. Holle DM, Stankovics ME, Sarna CS, Aguirre GD. The geographic form of retinal dysplasia in dogs is not always a congenital abnormality. Vet Ophthalmol. 1999;2(1):61-66.

  26. Acland GM, Aguirre GD, Ray J, Zhang Q, Aleman TS, Cideciyan AV, Pearce-Kelling SE, Anand V, Zeng Y, Maguire AM, Jacobson SG, Hauswirth WW, Bennett J. Gene therapy restores vision in a canine model of childhood blindness. Nat Genet. 2001 May;28(1):92-5.

  27. Syed N, Smith JE, John SK, Seabra MC, Aguirre GD, Milam AH. Evaluation of retinal photoreceptors and pigment epithelium in a female carrier of choroideremia. Ophthalmology. 2001 Apr;108(4):711-20.

  28. Pearce-Kelling SE, Aleman TS, Nickle A, Laties AM, Aguirre GD, Jacobson SG, Acland GM. Calcium channel blocker D-cis-diltiazem does not slow retinal degeneration in the PDE6B mutant rcd1 canine model of retinitis pigmentosa. Mol Vis. 2001 Feb 25;7:42-7.

  29. John SK, Smith JE, Aguirre GD, Milam AH. Loss of cone molecular markers in rhodopsin-mutant human retinas with retinitis pigmentosa. Mol Vis. 2000 Nov 3;6:204-15.

  30. Das M, Sakul H, Kong J, Acland GM, Pelletier J. A set of canine interrepeat sequence PCR markers for high-throughput genotyping. Physiol Genomics. 2000 Nov 9;4(1):13-24.

  31. Du F, Acland GM, Ray J. Cloning and expression of type II collagen mRNA: evaluation as a candidate for canine oculo-skeletal dysplasia. Gene. 2000 Sep 19;255(2):307-16.

  32. Zeiss, C.J., Ray, K., Acland, G.M., Aguirre, G.D. Mapping of X-Linked Progressive Retinal Atrophy (XLPRA), the Canine Homolog of Retinitis Pigmentosa 3 (RP3). Human Molecular Genetics 9(4):531-7, 2000.

  33. Zhang, Z., Ray, K., Acland, G.M., Czarnecki, J.M., Aguirre, G.D., Molecular cloning, characterization and expression of a novel retinal cluster protein cDNA. Gene 243(1-2):151-160, 2000.

  34. Zeiss, C.J., Acland, G.M., Aguirre, G.D. Retinal Pathology of Canine X-linked Progressive Retinal Atrophy, the Locus Homolog of RP3. Inv. Ophthalm. Vis. Sci. 40(13):3292-3304, 1999.

  35. Anderson, R.E., Maude, M.B., Alvarez, R.A., Acland, G., Aguirre, G.D. A hypothesis to explain the reduced blood levels of docosahexaenoic acid in inherited retinal degenerations caused by mutations in genes encoding retinal specific proteins. Lipids 34 Suppl:S235-237, 1999.

  36. Werner, P., Mellersh, C.S., Raducha, M.G., DeRose, S., Acland, G.M., Procuik, U., Wiegand, N., Aguirre, G.D., Henthorn. P.S., Patterson, D.F., Ostrander, E.A. Anchoring of canine linkage groups with chromosome-specific markers. Mamm. Genome 10(8):814-823, 1999.

  37. Chen, H., Ray, J., Scarpino, V., Acland, G.M., Aguirre, G.D., Anderson, R.E. Synthesis and release of docosahexaenoic acid by the RPE cells of prcd-affected dogs. Invest. Ophthalmol. Vis. Sci. 40(10):2418-2422, 1999.

  38. Wang, W., Acland, G.M. Ray, K., Aguirre, G.D. Evaluation of cGMP-phosphodiesterase (PDE) subunits for causal association with rod-cone dysplasia 2 (rdc2), a canine model of abnormal retinal cGMP metabolism. Exp. Eye Res. 69(4):445-453, 1999.

  39. Wang, W, Zhang, Q., Acland, G., Mellersh, C., Ostrander, E., Ray, Aguirre, G. Molecular characterization and mapping of canine cGMP-phosphodiesterase delta subunit (PDE6D) GENE 236(2):325-332, 1999.

  40. Acland G, Ray K, Mellersh C, Langston, A, Rine J, Ostrander E, Aguirre, G. A Novel Retinal Degeneration Locus Identified by Linkage and Comparative Mapping of Canine Early Retinal Degeneration. Genomics 59(2):134-142, 1999.

  41. Gu, W., Ray, K., Pearce-Kelling, S., Baldwin, V., Langston, A., Ray, J., Ostrander, E., Acland, G. and Aguirre, G. Evaluation of the APOH gene as a positional candidate for prcd in dogs. Inv. Ophthalm. Vis. Sci. 40:1229-1237, 1999.

  42. Neff MW, Broman KW, Mellersh CS, Ray K, Acland GM, Aguirre GD, Ziegle JS, Ostrander EA, Rine J. A second-generation genetic linkage map of the domestic dog, Canis familiaris. Genetics 151: 803-820, 1999.

  43. Zhang, Q., Baldwin, V., Acland, G., Parshall, C.J., Haskell, J., Aguirre, G. and Ray, K. Photoreceptor dysplasia (pd) in miniature schnauzer dogs: evaluation of candidate genes by molecular genetic analysis. J. of Heredity 90: 57-61, 1999.

  44. Ray, K., Wang, W., Czarnecki, J., Zhang, Q., Acland, G. and Aguirre, G. Strategies for identification of mutations causing hereditary retinal diseases in dogs: evaluation of opsin as a candidate gene. J. of Heredity 90: 133-137, 1999.

  45. Gu, W., Post, C., Aguirre, G. and Ray, K. Individual DNA bands obtained by RAPD analysis of canine genomic DNA often contain multiple DNA sequences. J. of Heredity 90: 96-98, 1999.

  46. Aguirre, G. Baldwin, V., Weeks, K., Acland, G. and Ray, K. Frequency of the codon 807 mutation in the cGMP phosphodiesterase -subunit gene in Irish setters and other dog breeds with inherited retinal degeneration. J. of Heredity 90: 143-147, 1999.

  47. Langston, A., Mellersh, C., Wiegand, N., Acland, G., Ray, K., Aguirre, G. and Ostrander, E. Towards a framework linkage map of the canine genome. J. of Heredity 90: 7-14, 1999.

  48. Ray, K., Wang, W., Czarnecki, J., Acland, G. and Aguirre, G. Strategies for identification of mutations causing hereditary retinal diseases in dogs: evaluation of opsin as a candidate gene. J. of Heredity 90:133-137, 1999.

  49. Zeiss, C.J., Acland, G.M., Aguirre, G.D. and Ray, K. TIMP-1 expression is increased in X-linked progressive retinal atrophy despite its exclusion as a candidate gene. Gene 225: 67-76, 1998.

  50. Aguirre, G.D, Baldwin, B., Pearce-Kelling, S., Narfstrm, K., Ray, K. and Acland, G.M. Congenital stationary night blindness in the dog: common mutation in the RPE65 gene indicates founder effect. Molecular Vision4: 3, 1998.

  51. Zhang, Q., Acland, G., Parshall, C.J., Haskell, J., Ray, K. and Aguirre, G. Characterization of canine photoreceptor phosducin cDNA and identification of a sequence variant in dogs with photoreceptor dysplasia. Gene 215:231-239, 1998

  52. Gu, W., Acland, GM, Langston, AA, Ostrander, EA, Aguirre, GD and Ray, K. Identification of a RAPD marker linked to inherited progressive rod-cone degeneration (prcd) in dogs. Mammalian Genome 9:740-744, 1998.

  53. Akhmedov, N.B., Piriev, N.I., Pearce-Kelling, S., Acland, G.M., Aguirre, G.D. and Farber, D.B. Evaluation of Transducin -subunit as a candidate for inherited cone degeneration (cd) in the dog. Inv. Ophthalm. Vis. Sci. 39:1775-1781, 1998.

  54. Zeiss, CJ, Trepanier, LA, Aguirre, GD and Ray, K. A highly conserved microsatellite in the dystrophin gene of diverse mammalian species. Animal Genetics 29:224-227, 1998.

  55. Gu, W., Aguirre, GD and Ray, K. A simple and efficient method of detection single nucleotide polymorphism. Biotechniques 24: 836-837, 1998.

  56. Acland, G., Ray, K., Mellersh, C., Gu, W., Langston, A., Rine, J., Ostrander, E., and Aguirre, G. Linkage analysis and comparative mapping of canine progressive rod-cone degeneration (prcd) establishes potential locus homology with retinitis pigmentosa (RP17) in humans. Proc. Natl. Acad. Sci. USA. 95:3048-3053, 1998.

  57. Langston, A.A., Mellersh, C.S., Neal, C.L., Ray, K., Acland, G.M., Gibbs, M., Aguirre, G.D., Fournier, R.E.K. and Ostrander, E.A. Construction of a panel of canine-rodent hybrid cell lines for use in partitioning of the canine genome. Genomics 46:317-325, 1997.

  58. Mellersh, C. S., Langston, A.A., Acland, G.M., Fleming, M. A., Ray, K., Weigand, N.A., Francisco, L.V., Gibbs, M., Aguirre, G.D. and Ostrander, E.A. A linkage map of the canine genome. Genomics 46:326-336, 1997.

  59. Aguirre, G.D., Acland, G.M., Maude, M.B. and Anderson, R.E. Diets enriched in docosahexaenoic acid fail to correct progressive rod-cone degeneration (prcd) phenotype. Inv. Ophthalm. Vis. Sci. 38: 2387-2407, 1997.

  60. Wang, W., Aguirre, GD and Ray, K. PCR/RFLP marker in the canine transducin-gamma gene (GNGT1). Animal Genetics 28: 319-320, 1997.

  61. Zhang, Q., Pearce-Kelling, S., Acland, G.M., Aguirre, G.D. and Ray, K. Canine rod photoreceptor cGMP-gated channel protein-subunit: studies on the expression of the gene and characterization of the cDNA. Exp. Eye Res. 65: 301-309, 1997.

  62. Gu, W.K., Acland, G.M., Aguirre, G.D. and Ray, K. Evaluation of RAPD analysis for identification of polymorphisms in canine genomic DNA. Animal Biotech. 8(2): 207-219, 1997.

  63. Akhmedov, N.B., Piriev, N.I., Ray, K., Acland, G.M., Aguirre, G.D. and Farber, D.B.: Structure and analysis of transducin 3-subunit, a candidate for inherited cone degeneration (cd) in the dog. Gene 194, 47-56, 1997.

  64. Gropp, K.E., Huang, J.C. and Aguirre, G.D. : Differential expression of photoreceptor-specific proteins during disease and degeneration in the progressive rod-cone degeneration (prcd) retina. Exp. Eye Res. 64:875-886, 1997.

  65. Ray, K., Baldwin, V.J., Zeiss, C.J., Acland, G.M. and Aguirre, G.D. : Canine rod transducin -1: Cloning of the cDNA and evaluation of the gene as a candidate for progressive retinal atrophy. Curr. Eye Res. 16:71-77, 1997.

  66. Wang, W., Acland, G.M., Aguirre, G.D. and Ray, K. : Cloning and characterization of the cDNA and gene encoding the -subunit of the cGMP-phosphodiesterase in canine retinal rod photoreceptor cells. Gene 181: 1-5, 1996.

  67. Wang, W., Acland, G.M., Aguirre, G.D. and Ray, K. : Cloning and characterization of the cDNA encoding the -subunit of the cGMP-phosphodiesterase in canine retinal rod photoreceptor cells. Mol. Vis. 2:96002, 1996.

  68. Ray, K., Zeiss, C., Acland, G.M., Trepanier, L.A. and Aguirre, G.D. : A highly polymorphic RFLP marker in the canine transducin -1 subunit gene (GNAT1). Anim. Genet. 27:372-373, 1996.

  69. Ray, K., Trepanier, L.A., Acland, G.M., and Aguirre, G.D. : PCR/RFLP marker in the canine opsin gene. Anim. Genet. 27:293-294, 1996.

  70. Ray, K., Lara Tejero, M.D., Baldwin, V.J. and Aguirre, G.D. : An improved diagnostic test for rod cone dysplasia 1 (rcd1) using allele-specific polymerase chain reaction. Curr. Eye Res. Curr Eye Res. 15:583-587, 1996.

  71. Ray, K., Acland, G.M. and Aguirre, G.D. : Nonallelism of erd and prcd and exclusion of the canine RDS/peripherin gene as a candidate for both retinal degeneration loci. Inv. Ophthalm. Vis. Sci. 37:783-795, 1996.

  72. Gropp, K.E., Szl, ., Huang, J.C., Acland, G.M., Farber, D.B. and Aguirre, G.D. : Selective absence of cone outer segment 3-transducin immunoreactivity in hereditary cone degeneration (cd). Exp. Eye Res. 63:285-296, 1996.

  73. Ray, K., Baldwin, V., Acland, G. and Aguirre, G. : Molecular diagnostic tests for ascertainment of genotype at the rod cone dysplasia 1 (rcd1) locus in Irish setters. Curr. Eye Res.14:243, 1995.

  74. Alvarez, R., Aguirre,G., Acland, G.M. and Anderson, R.E.: Docosapentaenoic acid is converted to docosahexaenoic acid in the retinas of normal and prcd-affected miniature poodles. Inv Ophth Vis Sci 35: 402-408, 1994.

  75. Ray, K., Baldwin, V., Acland, G., Blanton, S. and Aguirre, G. : Co-segregation of codon 807 mutation of the rod cGMP phosphodiesterase gene (PDEB) in rcd1. Inv Ophth Vis Sci 35: 4291, 1994.

  76. Acland, G., Blanton, S.H., Hershfield, B. and Aguirre, G.:XLPRA: A canine retinal degeneration inherited as an X-linked trait.. Am J. Med. Gen. 52:27, 1994.

  77. Mieziewska, K., Szl, A., van Veen, T., Aguirre, G. and Philp, N.: Redistribution of insoluble interphotoreceptor matrix components during photoreceptor differentiation in the mouse retina. J. Comp. Neurol. 345:115, 1994.

  78. van Winkle, T., Fyfe, J., Dayrell-Hart, B., Aguirre, G., Acland, G. and Patterson, D.: Blindness due to polymicrogyria and asymmetrical dilatation of the lateral ventricles in standard poodles. Prog. Vet. Neurol. 5:66, 1994.

  79. Huang, J., Chesselet, M.-F., and Aguirre, G.: Decreased opsin mRNA and immunoreactivity in progressive rod-cone degeneration (prcd):Cytochemical studies of early disease and degeneration. Exp. Eye Res.58:17, 1994.

  80. Anderson, R.E., Maude, M., Acland, G.M. and Aguirre, G.: Plasma Lipid Changes in prcd-Affected and Normal Miniature Poodles Given Oral Supplements of Linseed Oil. Indication for the Involvement of N-3 Fatty Acids in Inherited Retinal Degenerations. Exp. Eye Res. 58:129, 1994

  81. Mieziewska, K., van Veen, T. and Aguirre, G: Structural changes of the interphotoreceptor matrix in an inherited retinal degeneration: A lectin cytochemical study of progressive rod-cone degeneration (prcd). Inv. Ophthalm. Vis. Sc. 34:3056, 1993.

  82. Szl, A. Rhlich, P., Miewziewska, K., Aguirre, G. and vanVeen, T.: Spatial and Temporal Differences in the Expression of Short- and Middle-Wave Sensitive Cones in the Mouse Retina. A Developmental Study. J. Comp. Neurol. 331:564, 1993.

  83. Huang, J., Mieziewska, K., Philp, N., van Veen, T. and Aguirre, G.: Diethylene Glycol Distearate (DGD): A Versatile Embedding Medium for Retinal Cytochemistry. J. Neuroscience Methods 47:227, 1993.

  84. Miewziewska, K., vanVeen, T. and Aguirre, G. : Development and Fate of Interphotoreceptor Matrix Components During Dysplastic Photoreceptor Differentiation: A lectin cytochemical study of rod-cone dysplasia 1. Exp. Eye Res. 56:429, 1993.

  85. Szl, A., Rhlich, P., Caff, A.R., Juliusson, B., Aguirre, G. and van Veen, T.: Unique Topographic Separation of Two Spectral Classes of Cones in the Mouse Retina. J. Comp. Neurol. 325: 327, 1992.

  86. Farber, D., Danciger, J.S. and Aguirre, G. : The -Subunit of Cyclic GMP Phosphodiesterase mRNA is Deficient in Canine Rod-Cone Dysplasia 1. Neuron 9 : 349, 1992.

  87. Aguirre, G., van Veen, T. Jansen, H. and Sanyal, S. : Cytological Characterization of Surviving Immunoreactive Photoreceptors in the Retina of rd and rds Mice. Prog. Vet. Comp. Ophth.2: 65, 1992.

  88. Aguirre, G. and Acland, G.: Inherited Retinal Degeneration in the Labrador Retriever Dog. A New Animal Model of RP? Invest. Ophthalmol. Vis Sci. 32(4), 1991.

  89. Parshall, C., Wyman, M., Nitroy, S., Acland, G. and Aguirre, G. : Photoreceptor Dysplasia: An Inherited Progressive Retinal Atrophy of Miniature Schnauzer Dogs. Prog. Vet. Comp. Ophth. 1 :187, 1991.

  90. Mieziewska, K., vanVeen, T., Murray, J. and Aguirre, G. : Rod and Cone Specific Domains in the Interphotoreceptor Matrix. J. Comp. Neurol. 308 :371, 1991.

  91. Long, K. and Aguirre, G. : The Cone Matrix Sheath in the Normal and Diseased Retina. Exp. Eye Res. 52 : 699, 1991.

  92. Wiggert, B., Kutty, G., Long, K., Inouye, L., Gery, I., Chader, G. and Aguirre, G.: Interphotoreceptor Retinoid-Binding Protein (IRBP) in Progressive Rod-Cone Degeneration (prcd). Exp. Eye Res. 53 : 389, 1991.

  93. Anderson, R., Maude, M., Alvarez, R., Acland, G. and Aguirre, G.: Plasma Lipid Abnormalities in the Miniature Poodle with Progressive Rod-Cone Degeneration. Exp. Eye Res. 52 : 349, 1991.

  94. Jansen, H.G., Aguirre, G.D. and Sanyal, S.: Development and Degeneration of retina in rds Mutant Mice: Ultraimmunohistochemical Localization of S-Antigen. Curr. Eye Res. 9 : 903, 1990.

  95. Acland, G., Halloran-Blanton, S., Boughman, J. and Aguirre, G.: Segregation Distortion in Inheritance of Progressive Rod-Cone Degeneration (prcd) in Miniature Poodle Dogs. Am. J. Med. Gen. 35 : 354, 1990.

  96. Wetzel, M., Fahlman, C., O'Brien, P and Aguirre, G.: Metabolic Labeling of Rod Outer Segment Phospholipids in Miniature Poodles with Progressive Rod-Cone Degeneration (prcd). Exp Eye Res.50 : 89, 1990.

  97. Acland, G.M., Fletcher, R.T., Chader, G.J. and Aguirre, G.D.: Retinal Cyclic GMP and AMP in Rod-Cone Dysplasia : Comparisons of Assays in Fixed and Unfixed Canine Retinal Tissues. Ophthalmic Research 22 : 117, 1990.

  98. Aguirre, G.:.Progressive Retinal Atrophy in the Labrador Retriever is a Progressive Rod-Cone Degeneration (prcd).Proc. Am. Coll. Vet. Ophth, 1989.

  99. Acland, G. Fletcher, R.T., Gentleman, S., Chader, G. and Aguirre, G: Non-allelism of Three Genes (rcd 1, rcd 2 and erd) for Early-Onset Hereditary Retinal Degeneration. Exp. Eye Res.49 : 983, 1989.

  100. Wetzel M.G., Fahlman C.S., Alligood J.P., O'Brien P.J., Aguirre, G.D.: Metabolic Labeling of a Normal Canine Rod Outer Segment Phospholipids in Vivo and in Vitro. Exp. Eye Res. 48: 149, 1989.

  101. Barbehenn E, Gagnon C., Noelker D., Aguirre, G., Chader G: Inherited Rod-Cone Dysplasia: Abnormal Distribution of Cyclic GMP in Visual Cells of Affected Irish Setters. Exp. Eye Res 46: 149, 1988.

  102. Burns M.S., Bellhorn, R.W., Impellizzeri, C.W., Aguirre, G.D., Laties, A.M.: Development of Hereditary Tapetal Degeneration in the Beagle Dog. Current Eye Research 7: 103, 1988.

  103. Long, K., Philp, N., Gery, I. and Aguirre, G.: S-Antigen in a Hereditary Visual Cell Disease: Immunocytochemical and Immunological Studies. Inv. Ophth. Vis. Sci. 29: 1594, 1988.

  104. Aguirre G.D. and Acland G.M.: Variation in Retinal Degeneration Phenotype Inherited at the prcd Locus. Exp. Eye Res. 46: 663, 1988.

  105. Acland, G.M. and Aguirre, G.D.: Retinal Degenerations in the Dog: IV. Early Retinal Degeneration (erd) in Norwegian Elkhounds. Exp. Eye Res. 44: 491, 1987.

  106. Aguirre, G.D. and Andrews, L.: Nomarski Evaluation of Rod Outer Segment Renewal in a Hereditary Retinal Degeneration. Comparison with Autoradiographic Evaluation. Inv. Ophthal. and Vis. Sci. 28: 1049, 1987.

  107. Aguirre, G. and O'Brien, P.: Morphological and Biochemical Studies of Canine Progressive Rod-Cone Degeneration: 3H-Fucose Autoradiography. Invest. Ophthal. Vis. Sci. 27: 635, 1986.

  108. Fletcher, R.T., Sanyal, S., Krishna, G.,Aguirre, G.and Chader, G.J.:Genetic Expression of Cyclic GMP Phosphodiesterase Activity Defines Abnormal Photoreceptor Differentiation in Neurological Mutants of Inherited Retinal Degeneration. J. of Neurochem. 46:1240, 1986.

  109. Chader, G.J., Fletcher, R.T., Sanyal, S.and Aguirre, G.: A Review of the Role of Cyclic GMP in Neurological Mutants with Photoreceptor Dysplasia. Current Eye Research, 4: 811,1985.

  110. Schmidt, S.Y. and Aguirre, G.D.: Reductions in Taurine Secondary to Photoreceptor Loss in Irish Setters with Rod-Cone Dysplasia. Inv. Ophth. Vis. Sci. 26: 679, 1985.

  111. Sanyal, S., Fletcher, R., Liu, Y.P., Aguirre,G. and Chader, G.: Cyclic Nucleotide Content and Phosphodiesterase Activity in the rds Mouse (020/A) Retina. Exp. Eye Res. 38: 247, 1984.

  112. Meyers, V., Jezyk, P., Aguirre, G. and Patterson, D.: Short-limbed Dwarfism and Ocular Defects in the Samoyed Dog. JAVMA 183: 975, 1983.

  113. Aguirre, G., Farber, D., Lolley, R., O'Brien, P., Alligood, J., Fletcher, R.T., Chader, G.: Retinal Degenerations in the Dog: III Abnormal Cyclic Nucleotide Metabolism in Rod-Cone Dysplasia. Exp.Eye Res. 35: 625, 1982.

  114. Parkes, J., Aguirre, G., Rockey, J. and Liebman, P.: Progressive Rod-Cone Degeneration in the Dog: Characterization of the Visual Pigment. Inv. Ophth. Vis. Sci. 23: 674, 1982.

  115. Aguirre, G., Alligood, J., O'Brien, P. and Buyukmihci, N.: Pathogenesis of Progressive Rod-Cone Degeneration in Miniature Poodles. Inv. Ophth. Vis. Sci. 23: 610, 1982.

  116. Bellhorn, R., King, C., Aguirre, G., Ripps, H., Siegel, I. and Tsai, H.: Pigmentary Abnormalities of the Macula in Rhesus Monkeys: Clinical Observations. Inv. Ophth. Vis. Sci.21: 771, 1981.

  117. Chader, G., Liu, Y., Fletcher, T., Aguirre, G.,Santos-Anderson, R. and Tso, M.: Cyclic-GMP Phosphodiesterase and Calmodulin in Early-Onset Inherited Retinal Degenerations. Curr. Topics Membranes and Transport 15: 133, 1981.

  118. Valle, D., Boison, A., Jezyk, P. and Aguirre, G.: Gyrate Atrophy of the Choroid and Retina in a Cat. Inv. Ophth. Vis. Sci. 20: 251, 1981.

  119. Buyukmihci, N., Aguirre, G. and Marshall, J.: Retinal Degenerations in the Dog II. Development of the Retina in Rod-Cone Dysplasia. Exp. Eye Res. 30: 575, 1980.

  120. Chader, G., Liu, Y., O'Brien, P., Fletcher, R., Krishna, G.,Aguirre, G., Farber, D. and Lolley, R.: Cyclic GMP Phosphodiesterase Activator: Involvement in a Hereditary Retinal Degeneration. Neurochemistry 1: 441, 1980.

  121. Liu, Y.P., Krishna, G., Aguirre, G. and Chader, G.: Involvement of a Cyclic GMP Phosphodiesterase Activator in a Hereditary Retinal Degeneration. Nature 280: 62, 1979.

  122. Wetzel, D.A., Smith, E.L., Wilson, R.D. and Aguirre, G.D.:Congenital Stationary Night Blindness: An Animal Model. Invest.Ophth. 17: 788, 1978.

  123. Aguirre, G.D., Lolley, R., Farber, D., Fletcher, T. and Chader G.: Rod-Cone Dysplasia in Irish Setter Dogs: A Defect in Cyclic GMP Metabolism in Visual Cells. Science 201: 1133, 1978.

  124. Aguirre, G.D.:Retinal Degeneration Associated with the Feeding of Dog Foods to Cats. JAVMA 172: 791, 1978.

  125. Aguirre, G.D.: Retinal Degenerations in the Dog. I. Rod Dysplasia. Exp. Eye Res. 26: 233, 1978.

  126. Aguirre, G.D. and Laties, A.: Pigment Epithelial Dystrophy in the Dog. Exp. Eye Res. 23: 247, 1976.

  127. Aguirre, G.D.: Inherited Retinal Degenerations in the Dog Trans. Amer. Acad. Ophth. and Otol. 81: 667, 1976.

  128. Aguirre, G.D. and Rubin, L.F.: The Electroretinogram in Dogs with Inherited Cone Degeneration. Invest. Ophth. 14: 840, 1975.

  129. Aguirre, G.D. and Rubin, L.F.: Rod-Cone Dysplasia (Progressive Retinal Atrophy) in the Irish Setter. JAVMA 166: 157, 1975.

  130. Aguirre, G.D. and Rubin L.F.: Pathology of Hemeralopia in the Alaskan Malamute Dog. Invest. Ophth. 13: 231, 1974.

  131. Aguirre, G.D.: Electroretinography in Veterinary Ophthalmology. JAAHA 9: 234, 1973.

  132. Aguirre, G.D. and Rubin, L.F.: Progressive Retinal Atrophy in the Miniature Poodle: An Electrophysiologic Study. JAVMA 160: 191, 1972.

  133. Aguirre, G.D. and Rubin, L.F.: The Early Diagnosis of Rod Dysplasia in the Norwegian Elkhound. JAVMA 159: 429, 1971.

  134. Aguirre, G.D. and Rubin, L.F.: An Electrophysiologic Approach for Early Diagnosis of Progressive Retinal Atrophy in the Norwegian Elkhound. JAAHA 7: 136, 1971.

  135. Aguirre, G.D. and Rubin, L.F.: Progressive Retinal Atrophy (Rod Dysplasia) in the Norwegian Elkhound. JAVMA 158: 208, 1971.



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