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Primary Open Angle Glaucoma     POAG-Beagle    Code 310

Test Pricing

For breeds: Beagle

Similar to conditions seen in humans, Primary Open Angle Glaucoma (POAG) in the Beagle dog is an inherited disease that is characterized initially by increased intraocular pressure (IOP) and subsequently by serious ocular pathology that can include lens subluxation, cataracts and optic disk atrophy.

OptiGen offers a DNA test that is able to detect whether a dog carries 0, 1 or 2 copies of the mutation in the ADAMTS10 gene that causes POAG in the Beagle (1).  It is estimated that ~1% of the Beagle population carries this mutation.  There are other forms of glaucoma that are known to occur in a variety of dog breeds. To date, the ADAMTS10 mutation has only been observed in Beagles.

POAG in Beagles is inherited as an autosomal recessive trait, which means that individuals with two copies of the ADAMTS10 mutation, inherited from both parents, are at the highest risk of developing POAG. Carriers of only one copy of the mutation are not expected to develop the disease but will pass the mutation to their offspring. It is recommended not to breed two dogs together that carry one or two copies of the mutation in order to avoid producing offspring that are affected with POAG. For detailed recommendations on breeding strategies using results of OptiGen testing, please refer to the Breeding strategies chart below.


Expected results for breeding strategies using the
OptiGen test for POAG-Beagle
Parent 1
Genotype
Parent 2 Genotype
Normal/ClearCarrierAffected
Normal/ClearAll = Normal/Clear1/2 = Normal/Clear
1/2 = Carrier
All = Carrier
Carrier1/2 = Normal
1/2 = Carrier
1/4 = Normal/Clear
1/2 = Carrier
1/4 = Affected
1/2 = Carrier
1/2 = Affected
Affected All = Carrier
1/2 = Carrier
1/2 = Affected
All = Affected

References:

1. Kuchtey J Olson LM Rinkoski T Mapping of the disease locus and identification of ADAMTS10 as a candidate gene in a canine model of primary open angle glaucoma. PLoS Genet . 2011; 7: e1001306. 

 


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Tel: 607 257 0301 · Fax: 607 257 0353 · email: genetest@optigen.com or optigen@clarityconnect.com
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