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Golden Retriever PRA Type 2        GR_PRA2 Test       Code 206

For breeds: Golden Retriever

Following their success in identifying the GR_PRA1 mutation in 2011, the research team at the Animal Health Trust (AHT) in the UK and the Swedish University in Uppsala subsequently identified a mutation, GR_PRA2, that also causes Progressive Retinal Atrophy (PRA) in the golden retriever.  OptiGen is pleased to license the test from AHT for the pending patent's use in North and South America.

GR_PRA1 and 2, in combination with the OptiGen prcd-PRA test, enables us to identify nearly all causes of PRA in the breed.  Unfortunately, there are still a few cases of PRA in the golden retriever that are caused by as-yet unidentified mutations.  These cases will continue to be subject of ongoing PRA research.  if you know of any PRA-affected golden retrievers, please encourage the owners to contact OptiGen to learn about our free PRA testing/research program: (http://www.optigen.com/opt9_research.html)

As of July, 2013, frequency of the three known forms of PRA in the breed are as follows:

  • prcd-PRA: 8% of goldens tested at OptiGen carry the mutation
  • GR_PRA1: 5% of goldens tested at OptiGen carry the mutation
  • GR_PRA2: 3% of goldens tested at the Animal Health Trust carry the mutation (Many thanks to the researchers at AHT for providing GR_PRA2 statistics)

All three mutations are inherited in an autosomal recessive manner.  This means that disease will occur only if two copies of the same mutation are present; carriers of one copy of the mutations do not show disease.  Similar to planning matings with prcd-PRA and GR_PRA1 in mind, by ensuring that at least one parent is Normal/Clear for GR_PRA2, no GR_PRA2 offspring will be produced.  See the chart below for expected breeding outcomes when the GR_PRA2 status (Genotype) has been determined by testing.

Expected results for breeding strategies using the
GR_PRA2 test
Parent 1
Genotype
Parent 2 Genotype
Normal/ClearCarrierAffected
Normal/ClearAll = Normal/Clear1/2 = Normal/Clear
1/2 = Carrier
All = Carrier
Carrier1/2 = Normal
1/2 = Carrier
1/4 = Normal/Clear
1/2 = Carrier
1/4 = Affected
1/2 = Carrier
1/2 = Affected
Affected All = Carrier
1/2 = Carrier
1/2 = Affected
All = Affected

 


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OptiGen®, LLC · Cornell Business & Technology Park · 767 Warren Road, Suite 300 · Ithaca, New York 14850
Tel: 607 257 0301 · Fax: 607 257 0353 · email: genetest@optigen.com or optigen@clarityconnect.com
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