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Neuropathy in the Greyhound       NDRG1 Test       Code 362

 
For breeds: Greyhound

Greyhound Neuropathy is a neurological disease marked by muscle weakness, exercise intolerance and an odd “bunny-hopping” gait. Symptoms first appear clinically in young dogs at three to nine months of age and progress to the point where most affected dogs are euthanized within their first year. The disease is inherited as a monogenic autosomal recessive trait, meaning that Carriers show no symptoms. The DNA test for greyhound neuropathy allows breeders to ensure that their dogs will not produce any litters with this fatal disease.

OptiGen’s DNA test for greyhound neuropathy is based on the research of Dr. Cord Drögemüller at the University of Berne and his team who discovered the causal mutation in the NDRG1 gene. Dr. Drögemüller has provided OptiGen with exclusive endorsement and technical support, allowing OptiGen to provide the best choice in the USA for testing for this fatal disease.

Greyhound neuropathy is a relatively common problem in the show dog population of greyhounds. Dr. Drögemüller’s study of 245 greyhounds found 25% of the dogs tested carried the mutation.  As more greyhounds in the USA are tested, OptiGen will update the statistics on the occurrence of the mutation in the USA population of Greyhounds.

The table below shows the expected results from breeding dogs of each genetic status. It is important never to breed two carrier dogs, because on average 25% of the pups could be affected. One parent should always be clear/normal for the disease.

Expected results for breeding strategies using the
OptiGen mutation test for Greyhound Neuropathy
Parent 1
Genotype
Parent 2 Genotype
Normal/ClearCarrierAffected
Normal/ClearAll = Normal/Clear1/2 = Normal/Clear
1/2 = Carrier
All = Carrier
Carrier1/2 = Normal
1/2 = Carrier
1/4 = Normal/Clear
1/2 = Carrier
1/4 = Affected
1/2 = Carrier
1/2 = Affected
Affected All = Carrier
1/2 = Carrier
1/2 = Affected
All = Affected

Please follow the instructions at the link "Ship Sample" and submit the information at "Request Test".

References:

Drögemüller C et al. A Deletion in the N-Myc Downstream Regulated Gene 1 (NDRG1)Gene in Greyhounds with Polyneuropathy PLoS One. 2010 Jun 22;5(6):e11258.


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Tel: 607 257 0301 · Fax: 607 257 0353 · email: genetest@optigen.com or optigen@clarityconnect.com
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