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DNA Test for Ichthyosis (ICT-A) in the Golden Retriever

PLEASE NOTE: The Ichthyosis (ICT-A) test is performed in the laboratories of Antagene in France. There is typically a 3-4 week delay after OptiGen receives a sample before ICT-A test results are available for reporting.

ANTAGENE, a DNA research laboratory in France, has commercialized a DNA test that detects the mutation that causes Ichthyosis in the Golden Retriever.  In order to make this test more convenient for North American clients, OptiGen is pleased to serve as an agent for Antagene.  Orders for ICT-A may be placed through OptiGen's website and blood or cheek swab samples sent to our Ithaca, NY laboratory where they will be rendered into DNA and then shipped to Antagene for testing.  OptiGen will obtain results of the test from Antagene as soon as the tests are completed and send reports to the owners.  To request an Ichthyosis (ICT-A) DNA test go to order test.

Ichthyosis, whose name is derived from the Greek word for "fish" due to the fish-like scales that are observed on dogs with the disease, is a common inherited dermatosis observed in the Golden Retrievers of Europe and the United States.  Dogs with Ichthyosis develop white scales on the skin soon after birth.  The scales persist through the animal's life and progressively blacken, becoming dry and rough with age but typically do not cause itching.  Secondary infectious complications (bacterial, fungal or parasitic) are occasionally associated with the condition.

No specific or efficient treatments for Ichthyosis are currently available.  Treatments mainly rely on increased hygiene measures (e.g. frequent brushing, kerato-regulating shampoo, weekly emollients) and providing a fatty acid-enriched diet.

The Ichthyosis research that led to the mutation's discovery and the DNA test's validation was conducted by a canine genetic team from CNRS-University of Rennes (Dr. Catherine André), Dr. Eric Guaguère (Clinique Vétérinaire Saint-Bernard, 59160 Lomme, France) as well as their partners at ANTAGENE laboratory.  Antagene owns the international license for testing Ichthyosis (patent pending).

Golden Retriever Ichthyosis is inherited as an autosomal recessive trait.

The Antagene Ichthyosis (ICT-A) test detects the mutation and the normal ICT-A gene.  The result of the test is a genotype that separates dogs into three groups: Normal/Clear (homozygous normal), Carrier (heterozygous) and Affected (homozygous mutated).

 

Expected results for breeding strategies using the
Ichthyosis (ICT-A) test
Parent 1
Genotype
Parent 2 Genotype
Normal/Clear Carrier Affected
Normal/Clear All = Normal/Clear 1/2 = Normal/Clear
1/2 = Carrier
All = Carrier
Carrier 1/2 = Normal
1/2 = Carrier
1/4 = Normal/Clear
1/2 = Carrier
1/4 = Affected
1/2 = Carrier
1/2 = Affected
Affected All = Carrier
1/2 = Carrier
1/2 = Affected
All = Affected

 


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OptiGen®, LLC · Cornell Business & Technology Park · 767 Warren Road, Suite 300 · Ithaca, New York 14850
Tel: 607 257 0301 · Fax: 607 257 0353 · email: genetest@optigen.com or optigen@clarityconnect.com
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