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Neonatal Encephalopathy with Seizures      NEwS Test      Code 363

Test Pricing

For breed: Standard Poodle

Symptoms/Disease Description:

Neonatal Encephalopathy with Seizures (NEwS) in Standard Poodles is an inherited disease of the brain that becomes apparent soon after the pups are born. Affected pups are small, weak, uncoordinated, and mentally dull from birth. Many die during their first week of life. Those surviving past 1 week develop ataxia, a whole body tremor and, 4-5 weeks of age develop severe generalized seizures. Attempts to control these seizures with medication have proven unsuccessful, and the pups die or euthanized before they reach weaning age.

It is important to distinguish Neonatal Encephalopathy with Seizures from a number of brain diseases of young dogs that exhibit similar symptoms. For instance, low blood sugar levels or liver abnormalities can produce dullness and seizures in pups who aren't nursing well or who have congenital malformations other than NEwS. Low sugar levels and some abnormal liver functions can be diagnosed by appropriate blood tests and corrected by medication while abnormalities associated with NEwS cannot be cured.

The NEwS mutation test: 

Researchers from the University of Missouri-Columbia have identified a novel mutation in the ATF2 gene that causes Neonatal Encephalopathy with Seizures (NEwS) in Standard Poodles [1]. OptiGen is now pleased to provide Standard Poodle owners and breeders with a DNA test that detects the mutation and helps to make informed decisions about mating schemes to prevent the occurrence of this fatal developmental brain disease in the new progeny.

The DNA-based NEwS Test allows to determine genotype of a tested dog as being:

NORMAL - the dog has two copies of the normal gene and it is not going to develop Neonatal Encephalopathy with Seizures caused by the ATF2 gene.

CARRIER - the dog has one copy of the normal gene and one copy of the mutation. The dog will not develop clinical signs of the NEwS disease but it will transmit the mutation to about 50% of its progeny

AFFECTED - the dog has two copies of the mutation in the ATF2 gene and will develop the Neonatal Encephalopathy with Seizures caused by the mutation in the ATF2 gene.

Testing and Breeding recommendations:

NEwS in Standard Poodles is inherited as an autosomal recessive trait, which means that only dogs that have inherited two copies of mutant DNA (one copy from each parent) will develop this form of Neonatal Encephalopathy. Carriers of only one copy of the mutation will not develop the disease. 

To avoid producing NEwS-affected puppies, breeders are encouraged to test their Standard Poodles before they are bred, and to refrain from breeding two carriers to each other. The table below highlights in yellow the breedings that will NOT produce NEwS-affected pups. These breedings include at least one parent proven "Normal/Clear" by the OptiGen NEwS test. The Carrier to Carrier combination is at risk of producing NEwS-affected pups.

 

 

Expected results for breeding strategies using the
Neonatal Encephalopathy (NEwS) test

 

 

Parent 1
Genotype

 

Parent 2 Genotype

Normal/Clear

Carrier

Normal/Clear

All = Normal/Clear

1/2 = Normal/Clear
1/2 = Carrier

Carrier

1/2 = Normal
1/2 = Carrier

1/4 = Normal/Clear
1/2 = Carrier
1/4 = Affected

 

 References:

1. Chen X, Johnson GS, Schnabel RD, Taylor JF, Johnson GC, Parker HG, et al., A neonatal encephalopathy with seizures in standard poodle dogs with a missense mutation in the canine ortholog of ATF2. Neurogenetics (2008) 9:41-49.


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Tel: 607 257 0301 · Fax: 607 257 0353 · email: genetest@optigen.com or optigen@clarityconnect.com
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