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Spongy Degeneration with Cerebellar Ataxia subtype 1   

SDCA1 Test                                                        Code 259

For breeds: Belgian Malinois, Belgian Sheepdog (Groenendael), Belgian Laekenois, and Belgian Tervueren

Spongy Degeneration with Cerebellar Ataxia, subtype 1 (SDCA1) is an early onset form of severe neurodegenerative disease observed in the Belgian Malinois. Affected dogs show a rapidly progressing ataxia starting at 5-8 weeks of age. The affected puppies are usually euthanized by 8-12 weeks of age.

SDCA1 mutation test:
A collaborative effort between research groups from several laboratories in Austria and Switzerland has led to the identification of a causative mutation for this specific form of cerebellar dysfunction in the Belgian Malinois. Thanks to the assistance of technical support provided by the University of Bern researchers, OptiGen is pleased to offer the new SDCA1 mutation test.

The mutation is likely to occur in several other closely related breeds, i.e. Belgian Tervueren, Belgian Sheepdog (Groenendael), and Belgian Laekenois. The owners of these breeds are encouraged to use the SDCA1 test for testing the dogs if the presence of the disease is suspected in their breeding lines.

Testing/Breeding recommendations:
The SDCA1 in Belgian Malinois is an autosomal recessive disease. It means that individuals with two copies of the SDCA1 mutation, inherited from both parents, are at the highest risk of developing this form of Spongy Degeneration with Cerebellar Ataxia. Carriers of only one copy of the mutation are not expected to develop the disease but will pass the mutation to their offspring.

The SDCA1 test allows to determine the genotype of a tested dog as being Normal, Carrier or Homozygous Affected.

To avoid producing SDCA1-affected puppies, breeders are encouraged to test their dogs before they are bred, and to refrain from breeding two carriers to each other. The table below highlights in yellow the breedings that will NOT produce affected pups. These breedings include at least one parent proven "Normal/Clear" by the OptiGen SDCA1 test. 

 

Expected results for breeding strategies using the
  SDCA1 test
Parent 1
Genotype
Parent 2 Genotype
Normal/ClearCarrierAffected*
Normal/ClearAll = Normal/Clear1/2 = Normal/Clear
1/2 = Carrier
All = Carrier
Carrier1/2 = Normal
1/2 = Carrier
1/4 = Normal/Clear
1/2 = Carrier
1/4 = Affected
1/2 = Carrier
1/2 = Affected
Affected* All = Carrier
1/2 = Carrier
1/2 = Affected

All = Affected

*Since genetically Affected dogs usually die at a very young age, it is extremely unlikely that Affected dogs would survive to breeding age.


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OptiGen®, LLC · Cornell Business & Technology Park · 767 Warren Road, Suite 300 · Ithaca, New York 14850
Tel: 607 257 0301 · Fax: 607 257 0353 · email: genetest@optigen.com or optigen@clarityconnect.com
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