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Pyruvate Kinase Deficiency     PK Test      Code 367

Test Pricing

For breeds: Basenji

Please note cheek swabs are not accepted for this test.

Pyruvate kinase (PK) deficiency is an autosomal recessive inherited disease with multiple serious effects on the animal’s health. PK is an enzyme needed for normal energy production by the red blood cells. Its deficiency causes anemia and weakness, liver failure, abnormal bone density, heart murmur and shortened life expectancy.

Study of the PK gene in normal and affected Basenis revealed the specific mutation causing this disease. A DNA-based genetic test uses this information to identify dogs that are affected, carrier or normal.

Expected results of breeding strategies using OptiGen mutation tests for inherited recessive diseases
Parent 1
Genotype
Parent 2     Genotype
NormalCarrierAffected
NormalAll = Normal1/2 = Normal
1/2 = Carriers
All = Carriers
Carrier1/2 = Normal
1/2 = Carriers
1/4 = Normal
1/2 = Carriers
1/4 = Affected
1/2 = Carriers
1/2 = Affected
AffectedAll = Carriers1/2 = Carriers
1/2 = Affected
All = Affected
For information on recessive genetic diseases and the expected results for various breeding strategies, please go to the OptiGen “Glossary” link and read about “autosome” and “recessive”. The “recessive” table shows the expected results from breeding dogs of each genetic status. It is important never to breed two carrier dogs, because on average 25% of the pups could be affected. One parent should always be clear/normal for the disease.
 

Please follow the instructions at the link "Ship Sample" and submit the information at "Request Test". The cost of the PK test for Basenjis is $80 per test

Reference:

Whitney, KM, Lothrop CD. Genetic Test for Pyruvate Kinase Deficiency of Basenjis. Journal of the American Veterinary Medical Association. 1995. V 207 (7) 918-921.


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Tel: 607 257 0301 · Fax: 607 257 0353 · email: genetest@optigen.com or optigen@clarityconnect.com
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