Trapped Neutrophil Syndrome (TNS) Test:

For: Border Collie

 The TNS mutation is widely distributed, occurring in over 10% of the population of both working and show lines of Border Collies.  Dr. Wilton has worked closely with OptiGen, providing technical assistance and has endorsed OptiGen's offering of the TNS test that he and his research team have developed. We are pleased that OptiGen is now able to offer DNA testing at our laboratory in Ithaca, NY. If you would like to have a TNS test run on a sample from a Border Collie that you have previously tested through OptiGen, it is very likely that the DNA will still be archived from the original submission. Simply indicate on the order form that the sample is already at OptiGen. 

Similar to the other diseases in the Border Collie for which OptiGen offers DNA testing (CEA and CL), TNS is inherited in a simple autosomal recessive manner. Carriers do not show symptoms of the disease. The table below shows the expected results from breeding dogs of each genetic status. It is important never to breed two carrier dogs, because on average, 25% of the pups could be affected. At least one parent should always be clear/normal for the disease.